Radiotherapy has long been applied to treat various types of cancer.
However, efforts are still required to improve radiotherapy to be more productive, efficient and acceptable to patients as it currently has some limitations such as injury to normal cells or the development of radioresitant behavior in tumour cells. There have been numerous approaches to investigating the combination of radiotherapy and photodynamic therapy (PTD), but their therapeutic effects on malignant cells are still inconclusive.
A novel approach for the combination of the two methods was made by utilising radioluminescent organic nanoparticles (ONPs) doped with a photosensitiser. When NPs are irradiated by X-rays, the photosensitiser is also excited, which generates reactive oxygen species (ROS) in the presence of oxygen during radiotherapy. As the approach is expected to destroy the tumour cells via two distinct mechanisms (X-ray irradiation and ROS generation), the efficacy of radiotherapy may enhance. Thus, therapeutic doses and negative effects will be decreased.
Chemical Engineering and Advanced Materials
Dam Nha Uyen Nguyen